The German Acromegaly Register – Surgical outcome in 400 patients
Background: Treatment results for acromegaly remain unsatisfactory. Publications from experienced centres may not represent the overall situation.
Objective: The German Acromegaly Register (expected number of pts=5000 until 2013) documents diagnostic/therapeutic effectiveness, comorbidity/ mortality, compares experienced with not-experienced centres, extracts suggestions for improvement.
Methods: Two trained nurses visit all centres. Software of the UK Acromegaly Database is used.
Results: 502 patients from 18 centres entered as of Dec. 2003. Surgical results from 400 operated pts are reported (incomplete data from early time periods n=119). Basal, 1 and 3 yrs post-surgery GH/IGF-I data are given (Table). 3-yr data include secondary/tertiary treatment with repeat surgery (n=71), medical treatment (n=181), irradiation (n=68). Operative results improved during consecutive time periods, but cure rate did not surpass 54%. Secondary treatment offered little further improvement. Presurgical medical treatment (n=117) reduced GH less than surgery (39.6 -> 13.7 µ/L).
Presenting Author: Prof. Dr. Hans-Jürgen Quabbe / Free University Berlin / 12209 Berlin / Auguststr. 18 / Germany / 0049307721709